Guest post by Rud Istvan,
In the 3/19 Wuhan virus briefing with the FDA, team Trump made much of the possibilities for two therapeutic candidates, chloroquine and remdesivir. Having now done informed basic research on both, I found their stories intrinsically interesting, while enabling an early assessment of their chances of success. Hence this hopeful guest post.
Wuhan coronavirus is an enveloped positive sense single strand RNA virus, meaning its core genetic RNA code is just one long chain coding directly for several proteins, surrounded first by a protective viral protein capsid coat, and then a lipid membrane ?envelope? from which project so called ?E? (for envelope) and ?S? (for spike) proteins. The S protein is what the virus uses to bind to and then invade the lung?s epithelial cells in order to hijack those cell?s reproductive machinery to make copies of itself using its RNA polymerase, itself encoded…
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