Treatment with HCQ, Azithromycin, and Combination in Patients With COVID-19 Reduced In-Hospital Mortality

vor 1 Std.

https://www.ijidonline.com/article/S1201-9712(20)30534-8/fulltext

Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19

Samia Arshad, Paul Kilgore, Zohra S. Chaudhry, William O’Neill, Marcus ZervosHenry Ford COVID-19 Task Force ¹Open AccessPublished:July 01, 2020DOI:https://doi.org/10.1016/j.ijid.2020.06.099

Highlights

• As of May27, 2020 there are over 1,678,843 confirmed cases of COVID-19 claiming more than 100,000 lives in the Unites States. Currently there is no known effective therapy or vaccine.
• According to a protocol-based treatment algorithm, among hospitalized patients, use of hydroxychloroquine alone and in combination with azithromycin was associated with a significant reduction in-hospital mortality compared to not receiving hydroxychloroquine.
• Findings of this observational study provide crucial data on experience with hydroxychloroquine therapy, providing necessary interim guidance for COVID-19 therapeutic practice.

Abstract

Significance

The United States is in an acceleration phase of the COVID-19 pandemic. Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies.

Objective

The purpose of this study was to evaluate the role of hydroxychloroquine therapy alone and in combination with azithromycin in hospitalized patients positive for COVID-19.

Design

Multi-center retrospective observational study

Setting

The Henry Ford Health System (HFHS) in Southeast Michigan: large six hospital integrated health system; the largest of hospitals is an 802-bed quaternary academic teaching hospital in urban Detroit, Michigan.

Participants

Consecutive patients hospitalized with a COVID-related admission in the health system from March 10,2020 to May 2,2020 were included. Only the first admission was included for patients with multiple admissions. All patients evaluated were 18 years of age and older and were treated as inpatients for at least 48 hours unless expired within 24 hours.

Exposure

Receipt of hydroxychloroquine alone, hydroxychloroquine in combination with azithromycin, azithromycin alone, or neither.

Main Outcome

The primary outcome was in-hospital mortality.

Results

Of 2,541 patients, with a median total hospitalization time of 6 days (IQR: 4-10 days), median age was 64 years (IQR:53-76 years), 51% male, 56% African American, with median time to follow-up of 28.5 days (IQR:3-53). Overall in-hospital mortality was 18.1% (95% CI:16.6%-19.7%); by treatment: hydroxychloroquine + azithromycin, 157/783 (20.1% [95% CI: 17.3%-23.0%]), hydroxychloroquine alone, 162/1202 (13.5% [95% CI: 11.6%-15.5%]), azithromycin alone, 33/147 (22.4% [95% CI: 16.0%-30.1%]), and neither drug, 108/409 (26.4% [95% CI: 22.2%-31.0%])​.Primary cause of mortality was respiratory failure (88%); no patient had documented torsades de pointes. From Cox regression modeling, predictors of mortality were age>65 years (HR:2.6 [95% CI:1.9-3.3]), white race (HR:1.7 [95% CI:1.4-2.1]), CKD (HR:1.7 [95%CI:1.4-2.1]), reduced O2 saturation level on admission (HR:1.5 [95%CI:1.1-2.1]), and ventilator use during admission (HR: 2.2 [95%CI:1.4-3.3]). Hydroxychloroquine provided a 66% hazard ratio reduction, and hydroxychloroquine + azithromycin 71% compared to neither treatment (p < 0.001).

Conclusions and Relevance

In this multi-hospital assessment, when controlling for COVID-19 risk factors, treatment with hydroxychloroquine alone and in combination with azithromycin was associated with reduction in COVID-19 associated mortality. Prospective trials are needed to examine this impact._____________________

For a news story on this:  https://www.foxnews.com/politics/hydroxychloroquine-helped-save-coronavirus-study

For more:https://madisonarealymesupportgroup.com/2020/06/30/dr-meryl-nass-discovers-hydroxychloroquine-experiments-were-designed-to-kill-covid-patients-how-many-were-murdered/Excerpt:Dr. Meryl Nass has uncovered a hornet’s nest of government sponsored Hydroxychloroquine experiments that were designed to kill severely ill, Covid-19 hospitalized patients. On June 14^th Dr. Nass first identified two Covid-19 experiments in which massive, high toxic doses – four times higher than safeof hydroxychloroquine were being given to severely ill hospitalized patients in intensive care units.

• https://madisonarealymesupportgroup.com/2020/06/09/hcq-breakthrough-icmr-finds-its-effective-in-preventing-coronavirus-expands-its-use/

• https://madisonarealymesupportgroup.com/2020/05/22/new-study-hcq-zinc-greatly-reduces-covid-19-health-risk/

• https://madisonarealymesupportgroup.com/2020/05/11/podcast-evidence-supporting-hcq-azithromycin-for-covid-19/

• https://madisonarealymesupportgroup.com/2020/03/27/the-truth-about-hydroxychloroquine-plaquenil-in-the-treatment-of-covid-19/

• https://madisonarealymesupportgroup.com/2020/04/24/dr-oz-interviews-dr-didier-raoult-on-hydroxychloroquine-study-for-covid-19/

• https://madisonarealymesupportgroup.com/2020/06/01/rebuttal-on-huge-hcq-study-in-lancet/

• https://madisonarealymesupportgroup.com/2020/06/16/aaps-sues-fda-for-irrational-interference-of-access-to-life-saving-hydroxychloroquine/

• https://madisonarealymesupportgroup.com/2020/06/24/influence-of-conflicts-of-interest-on-public-positions-in-the-covid-19-era-the-case-of-gilead-sciences/

Regarding the anti-viral Remdesivir:  https://madisonarealymesupportgroup.com/2020/07/02/remdesivir-for-covid-19-not-backed-by-results/

Excerpt: 

Remdesivir isn’t cheap.  In fact, this article states it costs $320 per vial and will be sold for $3,120 per 6 vial treatment:  https://www.thegatewaypundit.com/2020/06/stunning-faucis-remdesivir-costs-9-per-dose-will-sold-3000-per-dose-china-company-linked-soros-will-also-mass-produce-drug/ That’s a lot of money for a drug that hasn’t even been shown to lower viral load.

Hydroxychloroquine in the other hand costs $1 per treatment, while chloroquine costs a measly 30 cents!  https://madisonarealymesupportgroup.com/2020/05/11/podcast-evidence-supporting-hcq-azithromycin-for-covid-19/

The article also points out an ugly conflict of interest web between Gilead, the manufacturer of Remdesivir and UNITAID which Soros, Gates, and the Clinton Health Access Initiative, are large investors – with Drs. Fauci and Birx associated with the Clinton Health Access initiative.  And of course, Dr. Fauci has worked with Gilead for a long, long time. Government employees should not be allowed to have financial ties to manufacturing companies and then turn around and make public health policy.

Excerpt:

Approximately $70 million in U.S. taxpayer funding began Gilead’s partnership with the U.S. Army, Centers for Disease Control and Prevention (CDC) and National Institutes of Health (NIH) to develop remdesivir. Initially for treating Ebola, it failed to show benefit and was shelved. If remdesivir is used to treat COVID-19, Gilead shareholders, not the taxpayers, will profit.

reatment with HCQ, Azithromycin, and Combination in Patients With COVID-19 Reduced In-Hospital Mortality — Madison Area Lyme Support Group

NH Lyme Insurance Bill Heads To Governor

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TOUCHED BY LYME: New Hampshire Lyme insurance bill heads to governor

Wendy Thomas and five of her six adult children have all been diagnosed with Lyme disease and co-infections. So, she knows a thing or two about what families go through to obtain proper treatment for tick-borne illness. And about how difficult it can be to get insurance companies to pay for it.

Wendy Thomas is also a New Hampshire state lawmaker. She has authored a Lyme insurance coverage bill that has now passed both houses of the legislature.

She explained it to me like this in an email:

The idea for this bill originated when I asked local docs who treat Lyme disease what kinds of changes to laws would help them. In New Hampshire, because a previous rep was sick with Lyme disease, we are allowed to prescribe antibiotics for long-term (and it’s covered by insurance). However, insurance would only cover 18 rounds of IV antibiotic therapy even if a doc thinks more is needed. This bill changes that and allows the doc to prescribe as she feels necessary and the insurance will now cover it. 

Click here to read the text of the bill.

The measure now heads to the desk of Governor Chris Sununu. Will he sign it into law? That remains to be seen. Stay tuned.

TOUCHED BY LYME is written by Dorothy Kupcha Leland, LymeDisease.org’s Vice-president and Director of Communications. She is co-author of When Your Child Has Lyme Disease: A Parent’s Survival Guide. Contact her at dleland@lymedisease.org.

___________________

**Comment**

For those of you who are asking why Wisconsin doesn’t do something like this, please understand that an undertaking like this might drag on for years so it requires an unwavering tenacity and commitment.  Most of us are patients who can not handle a lot of stress.  Politics is stressful, and watchdogging bill language particularly so.

Those experienced in this type of work tell me that bill language can and often changes in the eleventh hour which can make things much, much worse not only for patients but especially for the doctors who are treating Lyme/MSIDS appropriately.  The last thing we need is for those committed doctors to have even more to contend with than they already do.

Ideally, conferring with treating doctors AND those with bill experience would ensure a bill of this nature wouldn’t go side-ways.

NH Lyme Insurance Bill Heads To Governor — Madison Area Lyme Support Group

Happy 4th of July!

vor 1 Tag(en)

https://www.archives.gov/founding-docs/declaration-transcript

In Congress, July 4, 1776.

The unanimous Declaration of the thirteen united States of America, When in the Course of human events, it becomes necessary for one people to dissolve the political bands which have connected them with another, and to assume among the powers of the earth, the separate and equal station to which the Laws of Nature and of Nature’s God entitle them, a decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation.

We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the pursuit of Happiness.–That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed, –That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness. Prudence, indeed, will dictate that Governments long established should not be changed for light and transient causes; and accordingly all experience hath shewn, that mankind are more disposed to suffer, while evils are sufferable, than to right themselves by abolishing the forms to which they are accustomed. But when a long train of abuses and usurpations, pursuing invariably the same Object evinces a design to reduce them under absolute Despotism, it is their right, it is their duty, to throw off such Government, and to provide new Guards for their future security.–Such has been the patient sufferance of these Colonies; and such is now the necessity which constrains them to alter their former Systems of Government. The history of the present King of Great Britain is a history of repeated injuries and usurpations, all having in direct object the establishment of an absolute Tyranny over these States. To prove this, let Facts be submitted to a candid world.

He has refused his Assent to Laws, the most wholesome and necessary for the public good.

He has forbidden his Governors to pass Laws of immediate and pressing importance, unless suspended in their operation till his Assent should be obtained; and when so suspended, he has utterly neglected to attend to them.

He has refused to pass other Laws for the accommodation of large districts of people, unless those people would relinquish the right of Representation in the Legislature, a right inestimable to them and formidable to tyrants only.

He has called together legislative bodies at places unusual, uncomfortable, and distant from the depository of their public Records, for the sole purpose of fatiguing them into compliance with his measures.

He has dissolved Representative Houses repeatedly, for opposing with manly firmness his invasions on the rights of the people.

He has refused for a long time, after such dissolutions, to cause others to be elected; whereby the Legislative powers, incapable of Annihilation, have returned to the People at large for their exercise; the State remaining in the mean time exposed to all the dangers of invasion from without, and convulsions within.

He has endeavoured to prevent the population of these States; for that purpose obstructing the Laws for Naturalization of Foreigners; refusing to pass others to encourage their migrations hither, and raising the conditions of new Appropriations of Lands.

He has obstructed the Administration of Justice, by refusing his Assent to Laws for establishing Judiciary powers.

He has made Judges dependent on his Will alone, for the tenure of their offices, and the amount and payment of their salaries.

He has erected a multitude of New Offices, and sent hither swarms of Officers to harrass our people, and eat out their substance.

He has kept among us, in times of peace, Standing Armies without the Consent of our legislatures.

He has affected to render the Military independent of and superior to the Civil power.

He has combined with others to subject us to a jurisdiction foreign to our constitution, and unacknowledged by our laws; giving his Assent to their Acts of pretended Legislation:

For Quartering large bodies of armed troops among us:

For protecting them, by a mock Trial, from punishment for any Murders which they should commit on the Inhabitants of these States:

For cutting off our Trade with all parts of the world:

For imposing Taxes on us without our Consent:

For depriving us in many cases, of the benefits of Trial by Jury:

For transporting us beyond Seas to be tried for pretended offences

For abolishing the free System of English Laws in a neighbouring Province, establishing therein an Arbitrary government, and enlarging its Boundaries so as to render it at once an example and fit instrument for introducing the same absolute rule into these Colonies:

For taking away our Charters, abolishing our most valuable Laws, and altering fundamentally the Forms of our Governments:

For suspending our own Legislatures, and declaring themselves invested with power to legislate for us in all cases whatsoever.

He has abdicated Government here, by declaring us out of his Protection and waging War against us.

He has plundered our seas, ravaged our Coasts, burnt our towns, and destroyed the lives of our people.

He is at this time transporting large Armies of foreign Mercenaries to compleat the works of death, desolation and tyranny, already begun with circumstances of Cruelty & perfidy scarcely paralleled in the most barbarous ages, and totally unworthy the Head of a civilized nation.

He has constrained our fellow Citizens taken Captive on the high Seas to bear Arms against their Country, to become the executioners of their friends and Brethren, or to fall themselves by their Hands.

He has excited domestic insurrections amongst us, and has endeavoured to bring on the inhabitants of our frontiers, the merciless Indian Savages, whose known rule of warfare, is an undistinguished destruction of all ages, sexes and conditions.

In every stage of these Oppressions We have Petitioned for Redress in the most humble terms: Our repeated Petitions have been answered only by repeated injury. A Prince whose character is thus marked by every act which may define a Tyrant, is unfit to be the ruler of a free people.

Nor have We been wanting in attentions to our Brittish brethren. We have warned them from time to time of attempts by their legislature to extend an unwarrantable jurisdiction over us. We have reminded them of the circumstances of our emigration and settlement here. We have appealed to their native justice and magnanimity, and we have conjured them by the ties of our common kindred to disavow these usurpations, which, would inevitably interrupt our connections and correspondence. They too have been deaf to the voice of justice and of consanguinity. We must, therefore, acquiesce in the necessity, which denounces our Separation, and hold them, as we hold the rest of mankind, Enemies in War, in Peace Friends.

We, therefore, the Representatives of the united States of America, in General Congress, Assembled, appealing to the Supreme Judge of the world for the rectitude of our intentions, do, in the Name, and by Authority of the good People of these Colonies, solemnly publish and declare, That these United Colonies are, and of Right ought to be Free and Independent States; that they are Absolved from all Allegiance to the British Crown, and that all political connection between them and the State of Great Britain, is and ought to be totally dissolved; and that as Free and Independent States, they have full Power to levy War, conclude Peace, contract Alliances, establish Commerce, and to do all other Acts and Things which Independent States may of right do. And for the support of this Declaration, with a firm reliance on the protection of divine Providence, we mutually pledge to each other our Lives, our Fortunes and our sacred Honor.

__________________

**Comment**

Never were the words in this document more important than today.

Happy 4th of July! — Madison Area Lyme Support Group

General Michael Flynn and members of his family recited the oath to the Constitution and shared this with American patriots on the 4th of July. This man loves America. What liars the Obama Administration and Deep State operatives were to attempt to malign the great General Michael Flynn as an agent of Russia. Nothing could…

General Michael Flynn and Family Members Take Twitter by Storm on the 4th of July Reciting Oath to Defend America — The Gateway Pundit

Geht es nach offiziellen Zahlen, dann haben etwa 18 % der Bevölkerung die App zur Verfolgung von Corona-Infektionen  heruntergeladen. Viel Wind um fast Nichts, so die Meinung von Kritikern. Die App-Entwicklung hat etwa 20 Millionen Euro gekostet und nimmt viel Zeit der Regierung für allerlei Werbe-Pressekonferenzen in Anspruch. Einfache Rechnungen zeigen, dass die Wirkung – wie schon in Island vor Monaten demonstriert – nicht besonders gravierend sein dürfte.

Voraussetzung für die Wirksamkeit müsste zumindest den Erwartungen nach sein, dass jeder, der die App installiert, in seinem Umfeld wahrgenommene Erkrankungen als Signal erhielte, um dann die eigene weitere Umwelt durch eine Selbst-Quarantäne zu schützen. Die aktuelle Verbreitung hat der Dynamik nach bereits abgenommen.

Leistungsfähigkeit in Frage gestellt…

Die App kann tatsächlich nur feststellen, ob ein Mensch mit Smartphone, auf dem die App installiert ist, einem anderen Infizierten nahegekommen ist, der sowohl die App installiert hat und das Smartphone aktiv sowie bei sich hat, tatsächlich positiv getestet wurde und dies der App mitgeteilt hat.

Die Wahrscheinlichkeit dafür ist verschwindend gering. Überlegen wir kurz: Die erste Bedingung ist recht einfach zu erfüllen – die App sollte beidseitig installiert sein und das Smartphone angestellt sein. Dies vorausgesetzt wird es allerdings schon problematisch. Denn bei derzeit ungefähr 80 Millionen Menschen in Deutschland wäre das nur bei ungefähr jedem 6. Menschen der Fall, Kinder herausgerechnet bei jedem 3. Menschen. Hätten Sie die App installiert, müssten Sie statistisch betrachtet schon 5 tatsächlich infizierten Erwachsenen begegnen, damit ein zweiter Mensch zweiter Mensch außer Ihnen die App installiert hätte. 4 infizierte Menschen, denen Sie begegnen, hätten die App gar nicht installiert.

Wenn nun die Dunkelziffer der Infizierten bei einem Faktor von nur 3 läge, passierte folgendes: Auf jeden Infizierten, der sich vielleicht brav in der App einträgt, kommen weitere 3, die gar nicht wissen, dass sie infiziert sind. Das bedeutet nach der oben genannten Rechnung, dass Sie nicht nur 5, sondern wegen des Faktor 3 gleich 15 tatsächlich infizierten Menschen begegnen müssten, damit überhaupt einer dieser Menschen eine App installiert hätte. Jetzt muss dieser tatsächlich infizierte Mensch aber nicht nur von seiner Infektion wissen, die muss sich auch in den vergangenen 7 Tagen (wg. der Übertragbarkeit) ereignet haben und der Mensch muss diese Infektion auch in die App eingetragen haben – damit diese sie warnt. Wenn das bei 50 % der Menschen, die tatsächlich bekannt und frisch infiziert sind, der Fall ist, müssten Sie 30 tatsächlich infizierten Menschen begegnen, bis sie einmal gewarnt werden (die ursprüngliche Anzahl * 2).

Würde die App nun von 50 % (!) aller Menschen installiert, würde diese Rechnung sich wieder um den Faktor 3 (50 % statt nur 15 % mit App) verbessern. Dann also müssten Sie 10 tatsächlich infizierten Menschen begegnen, bis sie einmal gewarnt werden. Nehmen wir jetzt einfach mal diese Zahl. Das heißt aber umgekehrt, 9 von 10 tatsächlich infizierten Menschen mit Smartphone würden gar nicht zu einer Warnung führen. Die App wäre selbst dann rechnerisch weitgehend nutzlos. Warum gibt es die Nachverfolgungs-App dann in Deutschland? Bitte lesen Sie hier weiter…

Quelle: 20 Millionen Euro und viel Wind um Nichts? Die Corona-App der Regierung — NEOPresse – Unabhängige Nachrichten

Toledo Police Officer Anthony Dia was murdered on Independence Day morning while responding to a call in a Home Depot parking lot. Officer Dia was shot in the chest just after midnight on July 4th. Dia was dispatched to the area to make sure the man was OK. Officer Anthony leaves behind a wife and…

“Tell My Family I Love Them” – Not Making Headlines Today: Last Words of Murdered Police Officer Anthony Dia to Police Dispatch — The Gateway Pundit